Apollo 1: The Fire That Shocked NASA

The Apollo 1 Command Module after the fire that claimed the lives of Gus Grissom, Ed White, and Roger Chaffee. Credit: NASA.

NASA?s Apollo program began with one of the worst disasters the organization has ever faced. A routine prelaunch test turned fatal when a fire ripped through the spacecraft?s crew cabin killing all three astronauts. Today marks the 45th anniversary of the Apollo 1 fire, a tragic and preventable accident. There were warning signs, similar accidents that had claimed lives both in the United States and abroad. The Apollo 1 crew could have been saved from a gruesome death.

Plugs Out

L-R: Roger Chaffee, Ed White, and Gus Grissom training for their Apollo 1 flight. Credit: NASA.

The commander for Apollo 1 was Gus Grissom, one of the original Mercury astronauts whose first spaceflight was marred by his capsule?s sinking after splashdown. He flew again in Gemini in a spacecraft he named ?Molly Brown.? Senior pilot on the Apollo 1 crew was Ed White, a Gemini veteran who made America?s first spacewalk in 1965. Rounding out the crew was pilot Roger Chaffee, a talented rookie more than capable of holding his own with his experienced crew mates. He was a notoriously good guy who took pains to thank everyone for their contributions to Apollo right down to the janitors.

By the end of January 1967, the crew was going through their final prelaunch tests; barring some major setback, they would make the first manned Apollo flight on February 21. One routine test NASA had done since Mercury was the ?plugs out? test, a final check of the spacecraft?s systems.

The spacecraft – Command Module 12 – arrives at the Kennedy Spaceflight Centre clearly destined for Apollo 1. Credit: NASA.

The spacecraft was fully assembled and stacked on top of its unfuelled Saturn IB launch vehicle on pad 34. The umbilical power cords that usually supplied power were removed ? the plugs were out ? and the spacecraft switched over to battery power. The cabin was pressurized with 16.7 pounds per square inch (psi) of 100 percent oxygen, a pressure slightly greater than one atmosphere. With everything just as it would be on February 21, the crew went through a full simulation of countdown and launch.

A full launch-day staff of engineers in mission control also went through the simulation. The White Room, the room through which the astronauts entered the spacecraft, remained pressed next to the vehicle. A crew of engineers monitored the spacecraft and were just feet away from the astronauts.

Cosmonaut Bondarenko. Credit: spacefacts.de

Grissom, White, and Chaffee suited up and entered the Apollo 1 command module at 1pm and hooked into the spacecraft?s oxygen and communications systems. For the next five and a half hours, the test proceeded with only minor interruptions. Grissom?s complaint of a smell like sour buttermilk in the oxygen circulating through his suit was resolved after a short hold, and a high oxygen flow through the astronauts suits tripped an alarm. But these were minor problems and didn?t raise any red flags in mission control.

The real problem was communication. Static made it impossible for the crew and mission control to hear one another. An increasingly frustrated Grissom began to question how they were expected to get to the Moon if they couldn?t talk between a few buildings.

The Apollo 1 official crew portrait. L-R: Ed White, Gus Grissom, Roger Chaffee. Credit: NASA.

Just after 6:31 that evening, the routine test took a turn. Engineers in mission control saw an increase in oxygen flow and pressure inside the cabin. The telemetry was accompanied by a garbled transmission that sounded like ?fire.? The official record reflects the communications problem. The transmission was unclear, but the panic was obvious as an astronaut yelled something like ?they?re fighting a bad fire ? let?s get out. Open ?er up? or ?we?ve got a bad fire ? let?s get out. We?re burning up.? The static made it impossible to hear the exact words or even distinguish who was speaking.

But flames visible through the command module?s small porthole window left no doubt about what the crew had said. Engineers in the White Room tried to get the hatch open but couldn?t. It was an inward opening design, and neither engineers outside the spacecraft nor the astronauts inside were strong enough to force it open. The men in mission control watched helplessly as the scene played out on the live video feed.

The Apollo 1 crew in a less formal setting. L-R: Gus Grissom, Ed White, Roger Chaffee. Credit: NASA.

Just three seconds after the crew?s garbled report of a fire, the pressure inside the cabin became so great that the hull ruptured. Men wrestling with the hatch were thrown across the room as flames and smoke spilled into the White Room. Many continued to fight their way towards the spacecraft but were forced to retreat as the smoke grew too thick to see through. In mission control, the telemetry and voice communication from Apollo 1 went completely silent.

An hour and a half later, firemen and emergency personnel succeeded in removing the bodies; Ed White was turned around on his couch reaching for the hatch. Over the next two months, the spacecraft was disassembled piece by piece in an attempt to isolate the cause of the fire. The full investigation lasted a year.

The Apollo 1 crew floats around during water egress training. Credit: NASA.

The Apollo 1 accident review board determined that a wire over the piping from the urine collection system had arced. The fire started below the crew?s feet, so from their supine positions on their couches they wouldn?t have seen it in time to react. Everything in the cabin had been soaking in pure oxygen for hours, and flammable material near the wire caught fire immediately. From there, it took ten seconds for spacecraft to fill with flames.

The crew?s official cause of death was asphyxiation from smoke inhalation. Once their oxygen hoses were severed they began breathing in toxic gases. All three astronauts died in less than a minute. Many who had tried to save them were treated for smoke inhalation.

The Chamber of Silence

Astronaut Frank Borman’s official Gemini era portrait. Borman was the astronaut’s representative on the Apollo 1 accident review board. Credit: NASA.

The fire that claimed the lives of Grissom, White, and Chaffee is eerily similar to one that killed cosmonaut Valentin Bondarenko in 1961. Bondarenko was known to his colleagues as a congenial and giving man with great athletic prowess who worked tirelessly to prove he deserved the honour of flying in space.

Part of the cosmonauts? training was done in an isolation chamber designed to mimic the mental stresses spaceflight. The room, which the men called the Chamber of Silence, was spartan to say the least. It was furnished with a steel bed, a wooden table, a seat identical to what they would have in the Vostok capsule, minimal toilet facilities, an open-coil hot plate for warming meals, and a limited amount of water for washing and cooking. The chamber was pressurized to mimic the capsule?s environment in space. In this case, the oxygen concentration was 68 percent.

Ed White III touches his father’s name on the Apollo 1 panel of the Space Mirror Memorial at the Kennedy Space Centre visitor complex. Credit: NASA.

During the test, cosmonauts would exercise mental agility with memory games using a wall chart with coloured squares. They would keep busy by reading or colouring ? subjects were supplied with some leisure material. The silence was frequently interrupted by classical music to see how the subjects reacted to a pleasurable shock. Aside from these distractions, sensory deprivation inside the chamber was absolute. The room was mounted on thick rubber shock absorbers that muffled any vibrations from movement outside, and the 16-inch thick walls absorbed any sound. The cosmonauts communicated with doctors by lights. A light told the subject to apply medical sensors to his body, and a light outside the chamber signaled to doctors that they could begin their tests. A different light would signal the end of the isolation test.

The environment was designed to challenge the cosmonauts? mental stability and adaptability. But the hardest part was that no subject knew beforehand how long his test would last. It could run anywhere from a few hours to weeks.

The Apollo 1 crew walks across the gantry before entering the spacecraft on January 27. Credit: NASA.

Bondarenko was the 17th cosmonaut to go into the Chamber of Silence and on March 23, his ten day test came to an end. A light signaled that technicians outside had started depressurizing the chamber to match the atmosphere outside. It was a routine part of the test, but this time it was interrupted by a fire alarm.

While he waited to leave the chamber, Bondarenko removed his biomedical sensors and wiped the adhesive off with rubbing alcohol on a cotton pad. In his haste to leave, and exhibiting the lack of concentration expected after ten days of mental testing, he didn?t look where he threw the pad. It landed on the hot plate?s coil. Cosmonaut Pavel Popovich theorized that he had been standing next to it at the time. Many subjects left the small heater on all the time to warm up the chilly room.

A dummy rides in a Vostok capsule seat. Credit: Associated Press.

A fire sparked and spread in an instant; everything, including Bondarenko, was saturated with a high concentration of oxygen. Technicians wrenched the door open and exposed the chamber to air, killing the fire instantly, but the damage was done. Doctors pulled a huddled and severely burnt Bondarenko from the room. ?It?s my fault,? he whispered when doctors reached him, ?I?m so sorry? no one else is to blame.? The severity of the fire was immediately obvious. Bondarenko?s wool clothes had melted onto his body and the skin underneath had burned away. His hair had caught fire. His eyes were swollen and melted shut.

In Moscow, surgeon and traumatologist Vladimir Julievich Golyakhovsky got a frantic call at his office; the severely burned patient was on his way. Ten minutes later, a team of men in military uniforms arrived carrying the blanket-wrapped cosmonaut. They were accompanied, Golyakhovsky later recalled, by an overwhelming smell of burnt flesh.

The damage to the Apollo 1 crew cabin, after the bodies were removed and before the disassembly began. Credit: NASA.

Bondarenko pleaded for something ?to kill the pain.? Golyakhovsky obliged and gave the patient a shot of morphine in the soles of his feet. It was the one unscathed part of his body thanks to his heavy boots, and the only place the doctor could find a vein. There was nothing he could do to save the man?s life. Bondarenko died the next morning. The official cause was shock and severe burns.

Lessons at Home

Parallels between the Apollo 1 crew?s and Bondarenko?s deaths are obvious, but how each space agency dealt with the deaths was very different. Grissom, White, and Chaffee were each given very public funerals in accordance with their respective military traditions. Bondarenko?s death was kept secret, his identity covered by a pseudonym. Not until 1986 did the world hear the true story of his death. This has bred speculation that had the Soviet system been more open, NASA would have know about the dangers of training in a pressurized pure oxygen environment and could have saved the Apollo 1 crew. Former cosmonaut Alexei Leonov even suggested that the CIA knew about Bondarenko since the US had pierced the Iron Curtain before the accident.

But this is unlikely. And besides, NASA wouldn?t need to look to the Soviet Union to know the dangers of testing in a pressurized oxygen environment. There were enough incidents in the US to make the danger very clear. Four oxygen fires in the five years before the Apollo 1 accident were proof enough.

The Apollo 1 spacecraft nearing the end of the disassembly. Sometime towards the end of March, 1967. Credit: NASA.

On September 9, 1962, a fire broke out in a simulated spacecraft cabin at Brooks Air Force Base. The cabin was pressurized to 5psi with pure oxygen. Both subjects were protected by pressure suits. Neither sustained burns, but both were treated for smoke inhalation.

Two months later on November 16, four men had been inside the US Navy?s Air Crew Equipment Laboratory for 17 days in an environment pressurized to 5psi of 100 percent oxygen when an exposed wire arced and started a fire. It spread rapidly over the men?s clothing and hands for 40 seconds before they were rescued. All were treated for severe burns, and this was the only instance in which the source of the fire was identified.

Two Navy divers were killed on February 16, 1965 in a test of the Navy?s Experimental Diving Unit, which was pressurized to 55.6psi to mimic conditions at a depth of 92 feet. It was a multi-gas environment: 28 percent oxygen, 36 percent nitrogen, and 36 percent helium. Somehow, the carbon dioxide scrubbers that were designed to remove the toxic gas from the air caught fire. Pressure inside the chamber rose making it impossible for technicians outside to open the door and remove the men.

Gus Grissom’s funeral procession. Credit: NASA.

A 1966 oxygen environment fire came frighteningly close to anticipating the Apollo 1 accident. A fire broke out during an unmanned qualification test of the Apollo Environmental Control System on April 28. The cabin was pressurized to 5psi of 100 percent oxygen, just like the spacecraft would be in flight. The fire was blamed on a commercial grade strip heater inside the cabin and the incident was consequently dismissed. The commercial material would not be onboard any manned flights. The board that investigated the accident made no mention of the hazardous environment.

A Lack of Imagination

The Apollo 1 mission patch. Credit: NASA.

These accidents weren?t secret. NASA knew the dangers of a pressurized oxygen environment, which has prompted conspiracy theorists to suggest that the space agency intentionally put the Apollo 1 crew in danger. But this was hardly the case. In truth, no one at NASA gave much thought to a fire in the spacecraft.

In the early 1960s when Apollo was in its preliminary stages, a dual gas system (likely oxygen and nitrogen) was proposed for the crew cabin. This would have been safer in the event of fire, but more difficult overall. A mixed gas environment requires more piping and wiring, which in turn adds weight. Pure oxygen was simpler, lighter, and was already familiar to NASA. The dual-gas idea was scratched.

NASA did address the possibility of a fire in the spacecraft, but only developed procedures for an event in space when the nearest fire station was 180 miles away. Apollo, like Mercury and Gemini, had no specific fire fighting system on board. The 5psi of oxygen in space was considered too thin to feed a significant fire. Anything that could spark in that environment could be taken care of with a few well aimed blasts from the astronauts? water pistol.

Grissom’s, White’s, and Chaffee’s death are the cover story of Life Magazine’s February 10 issue. Credit: Life.

There was no procedure for a fire on the ground. With so many engineers on hand for every test, it was assumed that the astronauts would safe so long as fire extinguishers were nearby. But more importantly in the case of Apollo 1 is the plugs out test?s status: it wasn?t classified as dangerous.

Frank Borman, a Gemini veteran who would go to the Moon on Apollo 8, served as the astronaut?s representative to the Apollo 1 accident investigation board. He made this point about the plugs out test?s status abundantly clear. ?I don?t believe that any of us recognized that the test conditions for this test were hazardous,? he said on record. Without fuel in the launch vehicle and all the pyrotechnic bolts unarmed, no one imagined a fire could start let alone thrive. Borman himself hadn?t thought twice when he went through the plugs out test before his Gemini 7 mission. He was confident in NASA and its engineers and stated on record that he would have gone through the Apollo 1 test had he been on the crew.

The Apollo 1 crew expressed their concerns over the Apollo spacecraft in a joke crew portrait. They said a little prayer, and gave the picture to the manager of the Apollo Spacecraft Program Office Joe Shea in 1966. Credit: NASA.

Borman alluded to the Apollo 1 crew?s shared confidence. There had been problems with Apollo?w development, and every astronaut had the right to refuse to enter a spacecraft. ?Although there are sometimes romantic silk-scarf attitudes attributed to this type of business, in the final analysis we are professionals and will accept risk but not undue risks,? explained Borman. The Apollo 1 crew felt the dangers were minimal.

With that statement, Borman identified what he considered the crux of the problem and the real reason, however indirect, behind the death of the crew. ?We did not think,? he said, ?and this is a failing on my part and on everyone associated with us; we did not recognize the fact that we had the three essentials, an ignition source, extensive fuel and, of course, we knew we had oxygen.?

A plaque commemorating the Apollo 1 crew on what’s left of launch pad 34. Credit: Christopher K. Davis (via Wikipedia).

Gus Grissom serendipitously wrote his memoirs during the Gemini program. He addresses the inherent risk of spaceflight in the book?s final passage. ?There will be risks, as there are in any experimental program, and sooner or later, inevitably, we?re going to run head-on into the law of averages and lose somebody. I hope this never happens? but if it does, I hope the American people won?t feel it?s too high a price to pay for our space program. None of us was ordered into manned spaceflight. We flew with the knowledge that if something really went wrong up there, there wasn?t the slightest hope of rescue. We could do it because we had complete confidence in the scientists and engineers who designed and built our spacecraft and operated our Mission Control Centre? Now for the moon.?

Though tragic, their deaths were not in vain. The substantial redesigns made to the Apollo command module after the fire yielded a safer and more capable spacecraft that played no small role in NASA reaching the moon before the end of the decade. It is a fitting tribute to the crew that the plaque on the pad where they perished reads ?ad astra per aspera? ? a rough road to the stars.

Suggested Reading:

- Official Apollo 1 site:?http://www.hq.nasa.gov/office/pao/History/Apollo204/

- Colin Burgess and Rex Hall. The First Soviet Cosmonaut Team. 2009.

- Gus Grissom. Gemini. 1968.

- Apollo 204 Accident. Report of the Committee on Aeronautical and Space Science, United States. 1968. Available online:?http://klabs.org/richcontent/Reports/Failure_Reports/as-204/senate_956/index.htm

- Report of the Apollo 204 Review Board to the Administrator, National Aeronautics and Space Administration. 1968. Available online:?http://www.hq.nasa.gov/office/pao/History/Apollo204/content.html

- Hearings Before the Subcommittee on NASA Oversight of the Committee on Science and Astronautics. 1967.

Source: http://rss.sciam.com/click.phdo?i=0eace55ab634dec7f49ebc5b7e406a36

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96% The Muppets

All Critics (169) | Top Critics (40) | Fresh (162) | Rotten (6)

It may not entirely work as a movie, but The Muppets shines as a piece of touching pop nostalgia.

The purity of the nostalgia turns this franchise film into a love letter to childhood.

You can rest easy – if you have previously loved the Muppets, you will likely currently love The Muppets.

The chorus of one of the songs declares, ‘I’ve got everything that I need, right in front of me.’ For 120 minutes, that’s precisely how I felt.

[Filmmakers] hew close to the essential innocence informing the Muppets’ silliness.

The Muppets is a triumph of simplicity, innocence and goofy jokes. It’s a triumph of felt.

It’s never cloying or too knowing. Cynicism and wariness are real world concerns that have no place among the foam and felt.

Brushing aside decades of nostalgia, this is a whip-smart postmodern romp with a warm heart to boot, and as such, it should please both life-long fans and new initiates to the Muppet universe.

invites viewers to become a bit like the dreamer Walter and, in (re)discovering and embracing their inner child (not to mention their inner muppet), to join a fantastic, funny family that never grows old, no matter how times may have changed.

The innocence is slightly twisted, the harmonious camaraderie is slightly corrosive and the characters are slightly eccentric

I smiled throughout this madcap joyous adventure in which the Muppets are funny, silly, colourful and totally endearing in what must be the happiest film of the New Year

MY inner child – the one who loved The Muppet Show, The Muppet Movie and The Great Muppet Caper – really wants to give this film five stars.

By focusing on the Muppets of The Muppet Show (1976-1981) rather than the independent Muppets of prior films, the writers open up an unexplored aspect of Muppet lore ripe for revival.

A nice throwback to the good old days of the Muppets.

Under James Bobin’s direction, however, the outing feels cheap and strangely small-screen.

An altogether charming, smart and strangely moving little movie.

The Muppets may be one of the best films of the year, not judged as a children’s film, or a family film, but instead, simply as a film.

The Muppets is really two movies. And one of those movies is quite good, albeit awfully similar to previous films.

Even balcony critics Waldorf and Statler would have a hard time faulting this Wonkaful delight.

I am a fan of The Muppets and I’m glad to see them making a comeback. Maybe if this movie is a hit, they’ll make a sequel where they’ll actually get to be the stars of their own film.

A good imitation of the Muppet style.

The Muppets is a celebration of all things Muppets — filled with fun, laughter and moments of pure joy.

The Muppets heralds the return of Jim Henson’s beloved furry creations, resurrected from pop-culture irrelevance and lovingly restored to their former greatness in a vibrant comedy-musical.

The film’s success is owed to the fact that the living, breathing actors understand the show belongs to the Muppets. In their capable paws, claws, and flippers, the fun, kindness, and total, unadulterated wackiness of The Muppet Show is finally back.

More Critic Reviews

Source: http://www.rottentomatoes.com/m/the_muppets/

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Viruses con bacteria into working for them

[ Back to EurekAlert! ] Public release date: 26-Jan-2012
[ | E-mail | Share Share ]

Contact: Denise Brehm
brehm@mit.edu
617-253-8069
Massachusetts Institute of Technology, Department of Civil and Environmental Engineering

Co-evolution of guest and host lets a virus control its host’s machinery

MIT researchers have discovered that certain photosynthetic ocean bacteria need to beware of viruses bearing gifts: These viruses are really con artists carrying genetic material taken from their previous bacterial hosts that tricks the new host into using its own machinery to activate the genes, a process never before documented in any virus-bacteria relationship.

The con occurs when a grifter virus injects its DNA into a bacterium living in a phosphorus-starved region of the ocean. Such bacteria, stressed by the lack of phosphorus (which they use as a nutrient), have their phosphorus-gathering machinery in high gear. The virus senses the host’s stress and offers what seems like a helping hand: bacterial genes nearly identical to the host’s own that enable the host to gather more phosphorus. The host uses those genes, but the additional phosphorus goes primarily toward supporting the virus’ replication of its own DNA.

Once that process is complete (about 10 hours after infection), the virus explodes its host, releasing progeny viruses back into the ocean where they can invade other bacteria and repeat this process. The additional phosphorus-gathering genes provided by the virus keep its reproduction cycle on schedule.

In essence, the virus (or phage) is co-opting a very sophisticated component of the host’s regulatory machinery to enhance its own reproduction something never before documented in a virus-bacteria relationship.

“This is the first demonstration of a virus of any kind even those heavily studied in biomedical research exploiting this kind of regulatory machinery in a host cell, and it has evolved in response to the extreme selection pressures of phosphorus limitation in many parts of the global oceans,” says Sallie (Penny) W. Chisholm, a professor of civil and environmental engineering (CEE) and biology at MIT, who is principal investigator of the research and co-author of a paper published in the Jan. 24 issue of Current Biology. “The phage have evolved the capability to sense the degree of phosphorus stress in the host they’re infecting and have captured, over evolutionary time, some components of the bacteria’s machinery to overcome the limitation.”

Chisholm and co-author Qinglu Zeng, a CEE postdoc, performed this research using the bacterium Prochlorococcus and its close relative, Synechococcus, which together produce about a sixth of the oxygen in Earth’s atmosphere. Prochlorococcus is about one micron in diameter and can reach densities of up to 100 million per liter of seawater; Synechococcus is only slightly larger and a bit less abundant. The viruses that attack both bacteria, called cyanophages, are even more populous.

The bacterial mechanism in play is called a two-component regulatory system, which refers to the microbe’s ability to sense and respond to external environmental conditions. This system prompts the bacteria to produce extra proteins that bind to phosphorus and bring it into the cell. The gene carried by the virus encodes this same protein.

“Both the phage and bacterial host have the genes that produce the phosphorus-binding proteins, and we found they can both be up-regulated by the host’s two-component regulatory system,” says Zeng. “The positive side of infection for bacteria is that they will obtain more phosphorus binders from the phage and maybe more phosphorus, although the bacteria are dying and the phage is actually using the phosphorus for its own ends.”

In 2010, Chisholm and Maureen Coleman, now an assistant professor at the University of Chicago, demonstrated that the populations of Prochlorococcus living in the Atlantic Ocean had adapted to the phosphorus limitations of that environment by developing more genes specifically related to the scavenging of phosphorus. This proved to be the sole difference between those populations and their counterparts living in the Pacific Ocean, which is richer in phosphorus, indicating that the variation is the result of evolutionary adaptation to the environment.

The new research indicates that the phage that infect these bacteria have evolved right along with their hosts.

“These viruses the most abundant class of viruses that infect Prochlorococcus have acquired genes for a metabolic pathway from their host cells,” says Professor David Shub a biologist at the State University of New York at Albany. “These sorts of genes are usually tightly regulated in bacteria, that is they are turned into RNA and protein only when needed by the cell. However, genes of these kinds in viruses tend to be used in a strictly programmed manner, unresponsive to changes in the environment. Now Zeng and Chisholm have shown that these particular viral genes are regulated by the amount of phosphate in their environment, and also that they use the regulatory proteins already present in their host cells at the time of infection. The significance of this paper is the revelation of a very close evolutionary interrelationship between this particular bacterium and the viruses that seek to destroy it.”

“We’ve come to think of this whole system as another bit of evidence for the incredible intimacy of the relationship of phage and host,” says Chisholm, whose next steps are to explore the functions of all of the genes these marine phage have acquired from host cells to learn more about the selective pressures that are unique to the phage-host interactions in the open oceans. “Most of what we understand about phage and bacteria has come from model microorganisms used in biomedical research,” says Chisholm. “The environment of the human body is dramatically different from that of the open oceans, and these oceanic phage have much to teach us about fundamental biological processes.”

###


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?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


[ Back to EurekAlert! ] Public release date: 26-Jan-2012
[ | E-mail | Share Share ]

Contact: Denise Brehm
brehm@mit.edu
617-253-8069
Massachusetts Institute of Technology, Department of Civil and Environmental Engineering

Co-evolution of guest and host lets a virus control its host’s machinery

MIT researchers have discovered that certain photosynthetic ocean bacteria need to beware of viruses bearing gifts: These viruses are really con artists carrying genetic material taken from their previous bacterial hosts that tricks the new host into using its own machinery to activate the genes, a process never before documented in any virus-bacteria relationship.

The con occurs when a grifter virus injects its DNA into a bacterium living in a phosphorus-starved region of the ocean. Such bacteria, stressed by the lack of phosphorus (which they use as a nutrient), have their phosphorus-gathering machinery in high gear. The virus senses the host’s stress and offers what seems like a helping hand: bacterial genes nearly identical to the host’s own that enable the host to gather more phosphorus. The host uses those genes, but the additional phosphorus goes primarily toward supporting the virus’ replication of its own DNA.

Once that process is complete (about 10 hours after infection), the virus explodes its host, releasing progeny viruses back into the ocean where they can invade other bacteria and repeat this process. The additional phosphorus-gathering genes provided by the virus keep its reproduction cycle on schedule.

In essence, the virus (or phage) is co-opting a very sophisticated component of the host’s regulatory machinery to enhance its own reproduction something never before documented in a virus-bacteria relationship.

“This is the first demonstration of a virus of any kind even those heavily studied in biomedical research exploiting this kind of regulatory machinery in a host cell, and it has evolved in response to the extreme selection pressures of phosphorus limitation in many parts of the global oceans,” says Sallie (Penny) W. Chisholm, a professor of civil and environmental engineering (CEE) and biology at MIT, who is principal investigator of the research and co-author of a paper published in the Jan. 24 issue of Current Biology. “The phage have evolved the capability to sense the degree of phosphorus stress in the host they’re infecting and have captured, over evolutionary time, some components of the bacteria’s machinery to overcome the limitation.”

Chisholm and co-author Qinglu Zeng, a CEE postdoc, performed this research using the bacterium Prochlorococcus and its close relative, Synechococcus, which together produce about a sixth of the oxygen in Earth’s atmosphere. Prochlorococcus is about one micron in diameter and can reach densities of up to 100 million per liter of seawater; Synechococcus is only slightly larger and a bit less abundant. The viruses that attack both bacteria, called cyanophages, are even more populous.

The bacterial mechanism in play is called a two-component regulatory system, which refers to the microbe’s ability to sense and respond to external environmental conditions. This system prompts the bacteria to produce extra proteins that bind to phosphorus and bring it into the cell. The gene carried by the virus encodes this same protein.

“Both the phage and bacterial host have the genes that produce the phosphorus-binding proteins, and we found they can both be up-regulated by the host’s two-component regulatory system,” says Zeng. “The positive side of infection for bacteria is that they will obtain more phosphorus binders from the phage and maybe more phosphorus, although the bacteria are dying and the phage is actually using the phosphorus for its own ends.”

In 2010, Chisholm and Maureen Coleman, now an assistant professor at the University of Chicago, demonstrated that the populations of Prochlorococcus living in the Atlantic Ocean had adapted to the phosphorus limitations of that environment by developing more genes specifically related to the scavenging of phosphorus. This proved to be the sole difference between those populations and their counterparts living in the Pacific Ocean, which is richer in phosphorus, indicating that the variation is the result of evolutionary adaptation to the environment.

The new research indicates that the phage that infect these bacteria have evolved right along with their hosts.

“These viruses the most abundant class of viruses that infect Prochlorococcus have acquired genes for a metabolic pathway from their host cells,” says Professor David Shub a biologist at the State University of New York at Albany. “These sorts of genes are usually tightly regulated in bacteria, that is they are turned into RNA and protein only when needed by the cell. However, genes of these kinds in viruses tend to be used in a strictly programmed manner, unresponsive to changes in the environment. Now Zeng and Chisholm have shown that these particular viral genes are regulated by the amount of phosphate in their environment, and also that they use the regulatory proteins already present in their host cells at the time of infection. The significance of this paper is the revelation of a very close evolutionary interrelationship between this particular bacterium and the viruses that seek to destroy it.”

“We’ve come to think of this whole system as another bit of evidence for the incredible intimacy of the relationship of phage and host,” says Chisholm, whose next steps are to explore the functions of all of the genes these marine phage have acquired from host cells to learn more about the selective pressures that are unique to the phage-host interactions in the open oceans. “Most of what we understand about phage and bacteria has come from model microorganisms used in biomedical research,” says Chisholm. “The environment of the human body is dramatically different from that of the open oceans, and these oceanic phage have much to teach us about fundamental biological processes.”

###


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2012-01/miot-vcb012612.php

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Obama turns attention to energy in key states

President Barack Obama exits Air Force One after arriving in Las Vegas, Wednesday, Jan. 25, 2012. (AP Photo/John Gurzinski)

President Barack Obama exits Air Force One after arriving in Las Vegas, Wednesday, Jan. 25, 2012. (AP Photo/John Gurzinski)

(AP) ? President Barack Obama was returning Thursday to two states key to his re-election, Nevada and Colorado, promoting his energy agenda while grabbing some of the political spotlight ahead of his Republican rivals.

Both states hold their presidential caucuses within the next two weeks ? events that have grown in importance as the Republican contest for the White House appears to narrow to a choice between former Massachusetts Gov. Mitt Romney and former House Speaker Newt Gingrich.

Obama’s energy pitch also comes just days after he drew Republican criticism for rejecting a cross-country oil pipeline that would have delivered Canadian tar sands oil to refineries in Texas.

Obama will speak at a UPS center in Las Vegas and at Buckley Air Force Base in Colorado, drawing attention to proposals for clean energy and greater domestic oil and gas production.

Obama won both Nevada and Colorado in 2008. He visited both states in late October, using that trip to launch a phase of his campaign to jump-start the economy. With economic indicators improving, he now visits on a higher note.

Obama is drawing attention to two aspects of his energy policy ? greater domestic energy production and investment in cleaner energy sources.

The nearly 38-million-acre (153,780 square kilometer) parcel the Obama administration is putting up for lease is part of an offshore drilling plan for 2007-12 put in place by former President George W. Bush. But after the massive BP oil spill of 2010 led to an overhaul of the government’s oversight of offshore exploration and production, some areas had to be re-evaluated for the environmental risks associated with drilling.

The White House is portraying Obama as willing to seek the middle ground on energy after Republicans and the industry criticized him for the moratorium put in place after the Gulf disaster, the rejection of the Keystone XL pipeline from Canada, and other policies they say have hampered production, jobs and national energy security.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2012-01-26-Obama/id-603b6f6ea36d4cc5b9ce6782298b4b2b

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Video: Faber Report: Roche Launches Hostile Bid for Illumina

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Source: http://video.msnbc.msn.com/cnbc/46131310/

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Conoco says reaches China spill compensation deal (AP)

BEIJING ? ConocoPhillips said Wednesday that it and China National Offshore Oil Corp. reached a $160 million agreement to settle compensation claims from oil spills off northeastern China.

The Houston-based company said in a statement that the two had reached an agreement with China’s Ministry of Agriculture over the oil spills last June in the Bohai Sea.

The spills were considered small, especially compared with the Gulf of Mexico spills in 2010, but Conoco, the operator of the Bohai field, still came under intense media criticism in China.

Conoco said the money, 1 billion yuan, would be used “to settle public and private claims of potentially affected fishermen in relevant Bohai Bay communities.”

It said 10 percent of the money would go to the company’s previously announced fund to improve fishery resources.

The agreement will likely stop a lawsuit that a group of more than 100 Chinese fishermen filed last year seeking compensation from ConocoPhillips China for damage to their sea cucumber catches.

In September, ConocoPhillips announced plans to set up two funds to pay compensation and address environmental problems resulting from the spills.

The government has already ordered the company to stop all production pending a full cleanup and a review to ensure no more oil seeps into the sea.

The oil spill covered about 2,500 square miles (6,200 sq. kilometers) of water surface. It drew attention to pollution in the Bohai region due to industrialization, oil drilling and fast population growth that has decimated sea food and fish stocks and caused frequent red tides.

Sea cucumbers, one of many types of sea product harvested in the Bohai, are sausage-shaped, often spiky marine animals that are viewed as a delicacy by many in Asia.

Source: http://us.rd.yahoo.com/dailynews/rss/china/*http%3A//news.yahoo.com/s/ap/20120125/ap_on_bi_ge/as_china_oil_spill

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Eurpean Union test case: stop Hungary from backsliding on democracy

It’s hard to love the EU ? bureaucratic, legalistic, mired in gridlock. The euro crisis hasn’t earned it much praise lately, either. But the EU still has vital clout. It can help force member states like Hungary to stick to democracy, rather than backslide into dictatorship.

It is hard to love the European Union. Bureaucratic and legalistic, often mired in gridlock, it is little wonder that the EU has such trouble winning over the hearts and minds of European citizens or inspiring confidence internationally. The eurozone crisis has made all of this worse, with skeptics questioning whether the common currency or the EU itself will survive. But the EU?s mounting conflict with the Hungarian government reminds us why this union of 27 democratic nations remains so vital.

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In 2010, Viktor Orb?n and his party, Fidesz, won over two-thirds of the seats in Hungary?s parliament ? a majority large enough to amend the Hungarian Constitution. Since then, the Orb?n government has pushed through a slew of laws, constitutional amendments, and institutional reforms designed to remove any checks on his government and to consolidate his party?s hold on power for years to come.

The Orb?n government has passed laws attacking freedom of the press, freedom of religion, the independence of the judiciary, and the independence of Hungary?s central bank. They replaced Hungary?s previous electoral system with a new system designed to strongly favor Fidesz.

On Jan. 1, 2012, a new constitution went into effect ? a constitution designed to perpetuate Fidesz?s hold on power. The new constitution requires that laws in many key areas of public policy can only be changed by a two-thirds super-majority in parliament. Fidesz can use its current two-thirds majority to pass laws that future governments ? holding only a simple majority ? will be unable to change.

Moreover, the new constitution establishes extremely long terms of office for key positions in government, including the public prosecutor and heads of the new budget council, media board, and national judicial office. These positions have been staffed with Fidesz party loyalists who will remain in office for years, regardless of the outcome of the next election.

In December, as international criticism of his government?s actions mounted, Mr. Orb?n declared that no one in the world could tell the Hungarian parliament which laws to pass and which not to. Fortunately, he is wrong. In his bluster, Orb?n ignored the fact that Hungary has joined the European Union, making it subject to European law. Ultimately, the European Court of Justice can tell Hungary when its laws are unacceptable.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/RtfbW_jL8DQ/Eurpean-Union-test-case-stop-Hungary-from-backsliding-on-democracy

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Religion helps us gain self-control, study suggests

ScienceDaily (Jan. 24, 2012) ? Thinking about religion gives people more self-control on later, unrelated tasks; according to results from a series of recent Queen’s University study.

“After unscrambling sentences containing religiously oriented words, participants in our studies exercised significantly more self-control,” says psychology graduate student and lead researcher on the study, Kevin Rounding.

Study participants were given a sentence containing five words to unscramble. Some contained religious themes and others did not. After unscrambling the sentences, participants were asked to complete a number of tasks that required self-control — enduring discomfort, delaying gratification, exerting patience, and refraining from impulsive responses.

Participants who had unscrambled the sentences containing religious themes had more self-control in completing their tasks.

“Our most interesting finding was that religious concepts were able to refuel self-control after it had been depleted by another unrelated task,” says Mr. Rounding. “In other words, even when we would predict people to be unable to exert self-control, after completing the religiously themed task they defied logic and were able to muster self-control.”

“Until now, I believed religion was a matter of faith; people had little ‘practical’ use for religion,” Mr. Rounding explains. “This research actually suggests that religion can serve a very useful function in society. People can turn to religion not just for transcendence and fears regarding death and an after-life but also for practical purposes.”

Other members of the research team include psychology graduate student Albert Lee and Queen’s professors Jill Jacobson and Li-Jun Ji. The study was published in Psychological Science.

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Source: http://www.sciencedaily.com/releases/2012/01/120124113045.htm

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Study of freakish mystery illness finds no cause

This photo provided by Centers for Disease Control shows a case-patient with skin lesions, left, and a close-up of one of the lesions with mysterious blue fibers sprouting from the skin, published as part of a CDC study on Morgellons. Results of the CDC study released Wednesday, Jan. 25, 2012 conclude that Morgellons exists only in the patients’ minds. Sufferers of the mystery illness describe a variety of symptoms, including fatigue, erupting sores, crawling sensations on their skin and ? perhaps worst of all ? mysterious red, blue or black fibers that sprout from their skin. (AP Photo/CDC)

This photo provided by Centers for Disease Control shows a case-patient with skin lesions, left, and a close-up of one of the lesions with mysterious blue fibers sprouting from the skin, published as part of a CDC study on Morgellons. Results of the CDC study released Wednesday, Jan. 25, 2012 conclude that Morgellons exists only in the patients’ minds. Sufferers of the mystery illness describe a variety of symptoms, including fatigue, erupting sores, crawling sensations on their skin and ? perhaps worst of all ? mysterious red, blue or black fibers that sprout from their skin. (AP Photo/CDC)

FILE – In this Aug. 1, 2006 file photo, Verna Gallagher, who claims to be suffering from a rare infliction called, Morgellons, points to a sore on her skin that she believes bugs related to the condition emerged from, at her Roseville, Calif., home. Like others with the condition, Gallagher, 48, said she has a crawling sensation on her skin, that is caused by bugs that emerge from the skin but do not act like they are alive. Results of Centers for Disease Control study released Wednesday, Jan. 25, 2012 conclude that Morgellons exists only in the patients’ minds. (AP Photo/Rich Pedroncelli, File)

(AP) ? Imagine having the feeling that tiny bugs are crawling on your body, that you have oozing sores and mysterious fibers sprouting from your skin. Sound like a horror movie? Well, at one point several years ago, government doctors were getting up to 20 calls a day from people saying they had such symptoms.

Many of these people were in California and one of that state’s U.S. senators, Dianne Feinstein, asked for a scientific study. In 2008, federal health officials began to study people saying they were affected by this freakish condition called Morgellons.

The study cost nearly $600,000. Its long-awaited results, released Wednesday, conclude that Morgellons exists only in the patients’ minds.

“We found no infectious cause,” said Mark Eberhard, a Centers for Disease Control and Prevention official who was part of the 15-member study team.

The study appears in PLoS One, one of the Public Library of Science journals.

Sufferers of Morgellons (mor-GELL-uns) describe a variety of symptoms, including fatigue, erupting sores, crawling sensations on their skin and ? perhaps worst of all ? mysterious red, blue or black fibers that sprout from their skin. Some say they’ve suffered for decades, but the syndrome wasn’t named until 2002, when “Morgellons” was chosen from a 1674 medical paper describing similar symptoms.

Afflicted patients have documented their suffering on websites and many have vainly searched for a doctor who believed them. Some doctors believe the condition is a form of delusional parasitosis, a psychosis in which people believe they are infected with parasites.

Last May, Mayo Clinic researchers published a study of 108 Morgellons patients and found none of them suffered from any unusual physical ailment. The study concluded that the sores on many of them were caused by their own scratching and picking at their skin.

The CDC study was meant to be broader, starting with a large population and then went looking for cases within the group. The intent was to give scientists a better idea of how common Morgellons actually is.

They focused on more than 3 million people who lived in 13 counties in Northern California, a location chosen in part because all had health insurance through Kaiser Permanente of Northern California, which had a research arm that could assist in the project. Also, many of the anecdotal reports of Morgellons came from the area.

Culling through Kaiser patient records from July 2006 through June 2008, the team found ? and was able to reach ? 115 who had what sounded like Morgellons. Most were middle-aged white women. They were not clustered in any one spot.

That led to the finding that Morgellons occurred in roughly 4 out of every 100,000 Kaiser enrollees. “So it’s rare,” Eberhard said.

Roughly 100 agreed to at least answer survey questions, and about 40 consented to a battery of physical and psychological tests that stretched over several days.

Blood and urine tests and skin biopsies checked for dozens of infectious diseases, including fungus and bacteria that could cause some of the symptoms. The researchers found none that would explain the cases.

There was no sign of an environmental cause, either, although researchers did not go to each person’s house to look around.

They took fibers from 12 people, which were tested at the Armed Forces Institute of Pathology. Nothing unusual there, either. Cotton and nylon, mainly ? not some kind of organism wriggling out of a patient’s body.

Skin lesions were common, but researchers concluded most of them were from scratching.

What stood out was how the patients did on the psychological exams. Though normal in most respects, they had more depression than the general public and were more obsessive about physical ailments, the study found.

However, they did not have an unusual history of psychiatric problems, according to their medical records. And the testing gave no clear indication of a delusional disorder.

So what do they have? The researchers don’t know. They don’t even know what to call it, opting for the label “unexplained dermopathy” in their paper.

But clearly, something made them miserable. “The absence of evidence is not evidence of absence,” said Felicia Goldstein, an Emory University neurology professor and study co-author.

She said perhaps the patients could be helped by cognitive behavioral therapy that might help them deal with possible contributing psychological issues.

The study is not expected to be the last word on the subject.

Among those with additional questions is Randy Wymore, an Oklahoma State University pharmacologist who for years was the most reputable scientist to look into it and who has concluded Morgellons is not a psychiatric disorder.

On Wednesday, Wymore said he had not seen the CDC paper and was unable to comment on it. But when the study began, he questioned whether Kaiser patients with Morgellons would participate, especially if they were unhappy with how they were previously handled by their Kaiser doctors.

“There is always the question: How many of the study participants actually have Morgellons Disease?” he said, in an email.

The CDC is not planning additional study, however. The agency’s expertise is in infectious diseases and environmental health problems, and the researchers saw no evidence of that.

“We’re not mental health experts,” one CDC spokeswoman said.

___

Online:

PLoS One: http://www.plosone.org/home.action

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/bbd825583c8542898e6fa7d440b9febc/Article_2012-01-25-CDC-Morgellons%20Study/id-5903289376e6444a921402e709b67a2f

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Netflix customers return in 4Q; stock soars 16 pct (AP)

SAN FRANCISCO ? Netflix has regained almost as many customers as it lost following an unpopular price increase, signaling that the video subscription service is healing from its self-inflicted wounds.

Fourth-quarter figures released Wednesday show Netflix Inc. ended December with 24.4 million subscribers in the U.S., up from 23.8 million at the end of September. That gain of about 600,000 customers compares with the loss of 800,000 subscribers last summer after it raised its U.S. prices as much as 60 percent.

The uptick is a positive sign for Netflix after several months of upheaval battered its stock. The shares reversed course Wednesday, surging nearly 16 percent.

The fourth-quarter performance should help bolster confidence in Netflix CEO Reed Hastings, who was skewered in Internet forums and analyst notes for miscalculating how subscribers would react to higher prices.

A contrite Hastings had promised that Netflix would lure back customers, and so far it has been even more successful than he forecast.

“You are never as smart or dumb as they say,” Hastings said in a Wednesday interview. “We know we are just beginning to climb back in terms of consumer trust and affection.”

The fallout from the earlier customer defections contributed to a 14 percent decrease in Netflix’s fourth-quarter earnings.

Netflix made $40.7 million, or 73 cents per share, in the final three months of last year. That compares with income of $47.1 million, or 87 cents per share, a year earlier.

Investors had been bracing for a bigger drop-off. Analysts polled by FactSet had forecast fourth earnings of 54 cents per share.

Revenue climbed 47 percent from the previous year to $876 million ? $19 million above analyst projections.

Netflix’s stock soared $15.08, or nearly 16 percent, to $110.12 in extended trading. It had ended regular trading up $2.37, or 2.6 percent, at $95.04. If the rally carries over into Thursday’s trading, Netflix’s stock could close at its highest level in three months.

The stock still has a long way to go to return to its peak of nearly $305, which was reached in July, about the same time that Netflix announced the price increase that outraged customers.

“It’s still too early to know how much success Netflix is going to have this year, but seeing those gains in customers makes investors feel safer,” said Frost & Sullivan analyst Dan Rayburn.

Now that the backlash over the higher prices has eased, Netflix’s biggest challenge may be fending off competitive challenges to its primary business of streaming video over high-speed Internet connections.

Amazon.com Inc. is rapidly expanding a streaming service it started last year while many analysts are expecting Verizon Communications to get into video streaming later this year, possibly in a partnership with Coinstar Inc.’s Redbox, whose kiosks already compete against Netflix in DVD rentals. Google Inc.’s YouTube also is supplementing the amateur video on its site with more content from movie and TV studios.

Netflix, which is based in Los Gatos, Calif., also must navigate an international expansion that will saddle the company with a loss this year.

Those losses can be pared if Netflix can keep accelerating its customer growth.

The company forecast that it will add 1.7 million U.S. subscribers to its Internet video streaming service. That would be in line with how many streaming subscribers signed up in last year’s first quarter.

Netflix ended 2011 with 21.7 million streaming subscribers in the U.S. and another 1.9 million in Canada and Latin America. This month, Netflix introduced streaming plans in the United Kingdom and Ireland, too.

Most of the streaming gains will be offset by cancellations of DVD-by-mail rental plans, which Netflix is gradually phasing out. Hastings believes discs are becoming increasingly antiquated as technology advances. Netflix predicted its DVD subscriptions will fall from 11.2 million in December to 9.7 million in March. The company lost 2.8 million DVD subscribers in the fourth quarter.

“We expect DVD subscribers to decline every quarter forever,” Hastings told analysts during a Wednesday conference call.

About 8.4 million Netflix customers subscribe to both Internet streaming and DVD rentals.

While Netflix sees its emphasis on streaming as a smart long-term strategy, the DVD attrition will hurt the company’s full-year performance because Netflix’s recent price increases made delivering discs through the mail more profitable ? for now.

Netflix is paying higher fees for the streaming rights to exclusive programming, as well as video already available in other outlets and formats. At the end of December, its video licensing commitments totaled $3.9 billion.

Netflix expects to produce an annual loss this year, for the first time in a decade. The company gave the first inkling of how big the setback will be with its projection for a first-quarter loss of 16 cents to 49 cents per share.

Analysts on average expect a first-quarter loss of 29 cents per share.

Netflix projected first-quarter revenue of $842 million to $877 million, compared with a forecast for $849 million from analysts.

Source: http://us.rd.yahoo.com/dailynews/rss/tech/*http%3A//news.yahoo.com/s/ap/20120126/ap_on_hi_te/us_earns_netflix

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